Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 178
interventional 106
Observational 62
Registry 10

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 25
Device 20
Other 14
Procedure 14
Behavioral 7
Drug|placebo 5
Biological 4
Drug|Other 2
Behavioral|Drug|Other 1
Behavioral|Drug|placebo 1
Behavioral|Other 1
Biological|Drug|Procedure 1
Biological|Other 1
Biological|placebo 1
Biological|Procedure 1
Combination Product|Device 1
Device|Drug 1
Device|Drug|Procedure 1
Device|Other 1
Device|Procedure 1
Dietary Supplement 1
Dietary Supplement|placebo 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 36
China 9
Canada 8
NA 6
France 5
India 4
Korea, Republic of 4
Egypt 3
Japan 3
United Kingdom 3
Croatia 2
Italy 2
Sweden 2
Australia|New Zealand 1
Belgium 1
Bosnia and Herzegovina 1
Brazil 1
China|Hong Kong 1
Germany|Israel 1
Holy See (Vatican City State)|Italy 1
Hong Kong 1
Mexico 1
Netherlands 1
Norway 1
Russian Federation 1
Singapore 1
Switzerland 1
Taiwan 1
United States|Canada|New Zealand|United Kingdom 1
United States|Finland 1
United States|United Arab Emirates 1
Zambia 1

Sites per Study

Site_count Study_Count
1 75
2 6
3 2
4 2
6 4
7 2
8 5
9 1
10 2
11 1
16 1
18 1
22 2
25 1
27 1

Phase

Phase Study_Count
N/A 49
Phase 2 15
Phase 1 12
Phase 1/Phase 2 11
Phase 3 8
Phase 2/Phase 3 5
Phase 4 4
Early Phase 1 2

Number of Arms

Number_of_Arms Count_of_Studies
1 28
2 58
3 8
4 2
20 1
NA 9

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 7.00 10.0000 2.00000 13.00000 10.0 50.0 103.000 80
1st Qu. 15.25 34.0000 6.00000 27.00000 36.0 168.0 159.000 338
Median 23.50 60.0000 16.00000 45.00000 40.0 168.0 256.000 562
Mean 23.50 187.5918 24.58333 59.36364 64.6 153.2 5933.571 1426
3rd Qu. 31.75 112.0000 43.00000 76.00000 87.5 180.0 429.000 1650
Max. 40.00 1800.0000 60.00000 167.00000 176.0 200.0 40000.000 4500

Trial Group Type

group_type Group_Count
Experimental 107
Active Comparator 41
Placebo Comparator 19
No Intervention 16
Other 10
NA 9
Sham Comparator 3

Intervention Model

intervention_model Study_Count
Parallel Assignment 70
Single Group Assignment 30
Crossover Assignment 4
Sequential Assignment 2

Primary Purpose

primary_purpose Study_Count
Treatment 71
Prevention 19
Diagnostic 7
Other 3
Basic Science 2
NA 2
Health Services Research 1
Supportive Care 1

Observational Studies

Studies by Country

Country Study_Count
United States 18
China 7
France 5
Switzerland 5
United Kingdom 4
Denmark 2
Germany 2
Japan 2
NA 2
Canada 1
Czech Republic 1
Denmark|Sweden|United Kingdom 1
Egypt 1
Finland 1
France|Japan 1
Hong Kong 1
Ireland|Sweden 1
Norway 1
Spain 1
Sweden 1
Taiwan 1
Turkey 1
United States|Canada 1
United States|Canada|Thailand|United Kingdom 1

Sites per Study

Site_count Study_Count
1 47
2 5
5 1
6 3
7 1
8 2
9 1
22 1
26 1

Enrollment Metrics

Measure Observational
Min 4.0000
1st Qu 41.0000
Median 102.0000
Mean 599.8361
3rd Qu 300.0000
Max 11310.0000

Observation Model

observational_model Study_Count
Cohort 40
Case-Only 9
Case-Control 8
Case-Crossover 1
Case Control 1
Defined Population 1
Other 1
NA 1

Time Perspective

time_perspective Study_Count
Prospective 50
Retrospective 6
Cross-Sectional 3
Longitudinal, Prospective 1
Other 1
NA 1

Registries

Studies by Country

Country Study_Count
United States 3
Germany 2
Denmark 1
Egypt 1
Finland 1
France 1
Poland 1

Sites per Study

Site_count Study_Count
1 7
9 1
16 1
90 1

Enrollment Metrics

Measure Registries
Min 60.00
1st Qu 77.75
Median 215.00
Mean 8162.50
3rd Qu 7725.00
Max 60000.00

Registry Model

observational_model Study_Count
Cohort 7
Other 2
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 8
Other 2

Follow-up

target_duration Study_Count
1 Year 1
10 Years 1
12 Months 1
2 Years 1
21 Days 1
3 Months 1
4 Years 1
5 Years 1
6 Months 1
90 Days 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04217551 Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients https://ClinicalTrials.gov/show/NCT04217551 Recruiting University of Michigan 2024-06-30
NCT03396939 The Technology-assisted, High Intensive, Task-oriented Exercise Trial https://ClinicalTrials.gov/show/NCT03396939 Active, not recruiting Sunnaas Rehabilitation Hospital 2019-12-20
NCT03393559 Effect of Leg Elevation on Prevention of Intraoperative Hypotension During Beach Chair Position https://ClinicalTrials.gov/show/NCT03393559 Completed Seoul National University Hospital 2019-12-11
NCT03364296 Biological Dating of Cerebral Ischemia With GST-Ï€/PRDX1 to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis https://ClinicalTrials.gov/show/NCT03364296 Recruiting Central Hospital, Nancy, France 2021-07-13
NCT03352310 Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia https://ClinicalTrials.gov/show/NCT03352310 Recruiting Mononuclear Therapeutics Ltd. 2020-06-30
NCT03318783 Subarachnoid Hemorrhage and Soluble Epoxide Hydrolase Inhibition Trial https://ClinicalTrials.gov/show/NCT03318783 Active, not recruiting Oregon Health and Science University 2021-06-30
NCT03123081 Role of Umbilical Cord Milking in the Management of Hypoxic-ischemic Encephalopathy in Neonates https://ClinicalTrials.gov/show/NCT03123081 Recruiting Jubilee Mission Medical College and Research Institute 2020-12-31
NCT03116269 The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients https://ClinicalTrials.gov/show/NCT03116269 Completed Ajou University School of Medicine 2014-10-31
NCT03079284 Holding, Stress, and Bonding During Therapeutic Hypothermia https://ClinicalTrials.gov/show/NCT03079284 Completed Maine Medical Center 2017-09-23
NCT03079167 PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns https://ClinicalTrials.gov/show/NCT03079167 Recruiting University of Sydney 2021-12-31
NCT03071861 Mild Encephalopathy in the Newborn Treated With Darbepoetin https://ClinicalTrials.gov/show/NCT03071861 Recruiting University of New Mexico 2019-10-31
NCT03071783 Intra-operative Feed Back on Traction Force During Vacuum Extraction: Safe Vacuum Extraction Alliance https://ClinicalTrials.gov/show/NCT03071783 Completed Karolinska Institutet 2018-06-15
NCT02991976 Oxygen Concentration and Recovery After Carotid Endarterectomy https://ClinicalTrials.gov/show/NCT02991976 Completed Osijek University Hospital 2017-08-31
NCT02957123 Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome https://ClinicalTrials.gov/show/NCT02957123 Recruiting Russian Academy of Medical Sciences 2020-11-30
NCT02826941 Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT02826941 Completed Medical University of South Carolina 2004-06-30
NCT02819167 Brain and Cognitive Reserve https://ClinicalTrials.gov/show/NCT02819167 Completed Hospices Civils de Lyon 2016-08-31
NCT02735460 Usability of Andago V2.0 in Gait Rehabilitation of Stroke Patients https://ClinicalTrials.gov/show/NCT02735460 Completed Rehaklinik Zihlschlacht AG 2017-02-03
NCT02684825 Detection of Silent Atrial Fibrillation aFter Ischemic StrOke https://ClinicalTrials.gov/show/NCT02684825 Recruiting Azienda Policlinico Umberto I 2018-06-30
NCT02643030 Hypercapnia During Shoulder Arthroscopy https://ClinicalTrials.gov/show/NCT02643030 Completed Gachon University Gil Medical Center 2015-09-30
NCT02621944 Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia https://ClinicalTrials.gov/show/NCT02621944 Recruiting University of Florida 2021-03-31
NCT02618031 The Capillary Index Score Trial https://ClinicalTrials.gov/show/NCT02618031 Completed Akron General Medical Center 2018-08-31
NCT02612155 A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT02612155 Completed Duke University 2019-08-05
NCT02795052 Neurologic Stem Cell Treatment Study https://ClinicalTrials.gov/show/NCT02795052 Recruiting MD Stem Cells 2022-06-30
NCT02551003 Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy https://ClinicalTrials.gov/show/NCT02551003 Recruiting Children’s Hospital of Fudan University 2020-12-30
NCT02544542 Clinical Trial of a New Rectum Cooling System on Patients of Hypoxic-ischemic Brain Damage https://ClinicalTrials.gov/show/NCT02544542 Completed Children’s Hospital of Chongqing Medical University 2016-10-31
NCT02541591 Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients https://ClinicalTrials.gov/show/NCT02541591 Completed Universitaire Ziekenhuizen Leuven 2018-06-30
NCT02529202 Dexmedetomidine Pharmacokinetics in Neonates During Therapeutic Hypothermia https://ClinicalTrials.gov/show/NCT02529202 Completed Seattle Children’s Hospital 2016-11-30
NCT02453373 Helping Stroke Patients With ThermoSuit Cooling https://ClinicalTrials.gov/show/NCT02453373 Recruiting Life Recovery Systems 2020-07-31
NCT02448069 Safety and Feasibility of Argatroban, Tissue Plasminogen Activator and Intra-arterial Therapy in Stroke https://ClinicalTrials.gov/show/NCT02448069 Completed The University of Texas Health Science Center, Houston 2016-08-31
NCT02323685 Safety and Effect of SANGUINATEâ„¢ Infusion in Patients at Risk of Delayed Cerebral Ischemia (DCI) Following Subarachnoid Hemorrhage (SAH) https://ClinicalTrials.gov/show/NCT02323685 Completed Prolong Pharmaceuticals 2016-06-30
NCT02315443 Field Randomization of NA-1 Therapy in Early Responders https://ClinicalTrials.gov/show/NCT02315443 Recruiting NoNO Inc. 2021-05-31
NCT02287077 Umbilical Cord Milking for Neonates With Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT02287077 Completed Thomas Jefferson University 2016-10-31
NCT02256618 Autologous Cord Blood Cell Therapy for Neonatal Encephalopathy https://ClinicalTrials.gov/show/NCT02256618 Completed Neonatal Encephalopathy Consortium, Japan 2017-10-31
NCT02235974 Critical Periods After Stroke Study (CPASS) https://ClinicalTrials.gov/show/NCT02235974 Enrolling by invitation MedStar National Rehabilitation Network 2020-12-31
NCT02177981 Impact of Remote Ischemic Preconditioning Preceding Coronary Artery Bypass Grafting on Inducing nEuroprotection https://ClinicalTrials.gov/show/NCT02177981 Completed University of Zagreb 2015-10-31
NCT02119871 Comparative Effectiveness of Unilateral vs. Bilateral Pulmonary Collapse in Cardiac De-airing https://ClinicalTrials.gov/show/NCT02119871 Completed Lund University 2014-06-30
NCT02101606 Penumbral Based Novel Thrombolytic Therapy in Acute Ischemic Stroke https://ClinicalTrials.gov/show/NCT02101606 Completed University of Alberta 2017-11-30
NCT02071394 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth https://ClinicalTrials.gov/show/NCT02071394 Active, not recruiting University Hospitals Bristol NHS Foundation Trust 2019-10-07
NCT02056769 CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage https://ClinicalTrials.gov/show/NCT02056769 Active, not recruiting Nova Scotia Health Authority 2018-06-30
NCT01983618 Impact of Interscalene Nerve Block on Cerebral Perfusion During Surgery in the Beachchair Position https://ClinicalTrials.gov/show/NCT01983618 Completed Centre hospitalier de l’Université de Montréal (CHUM) 2015-02-28
NCT01936246 Protein Supplementation in Infants With Brain Injury https://ClinicalTrials.gov/show/NCT01936246 Completed Children’s Hospital Medical Center, Cincinnati 2014-03-31
NCT01915368 Determining Optimal Post-Stroke Exercise (DOSE) https://ClinicalTrials.gov/show/NCT01915368 Completed University of British Columbia 2019-12-31
NCT01875055 Reversing Cerebral Oxygen Desaturations Greater That 10% of Baseline Values Using NIRS in the ICU https://ClinicalTrials.gov/show/NCT01875055 Completed University of Manitoba 2014-06-30
NCT01862250 Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia https://ClinicalTrials.gov/show/NCT01862250 Completed Johns Hopkins University 2015-04-14
NCT01793129 Preemie Hypothermia for Neonatal Encephalopathy https://ClinicalTrials.gov/show/NCT01793129 Recruiting NICHD Neonatal Research Network 2020-08-31
NCT01787123 Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysinâ„¢ in Patients With Aneurysmal Subarachnoid Hemorrhage https://ClinicalTrials.gov/show/NCT01787123 Completed Kwong Wah Hospital 2019-01-01
NCT01765218 Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT01765218 Recruiting University of California, Davis 2020-05-31
NCT01749358 Dose Optimization for Stroke Evaluation https://ClinicalTrials.gov/show/NCT01749358 Completed University of Southern California 2016-08-31
NCT01699139 The Effect of Positional Device on the Obstructive Sleep Apnea in Patients With Ischemic Stroke https://ClinicalTrials.gov/show/NCT01699139 Completed Chang Gung Memorial Hospital 2014-07-31
NCT01683383 California Transport Cooling Trial https://ClinicalTrials.gov/show/NCT01683383 Completed Stanford University 2013-10-31
NCT01674452 Home-based Exercises for Patients With Stroke https://ClinicalTrials.gov/show/NCT01674452 Completed University of Sao Paulo General Hospital 2011-02-28
NCT01649648 Autologous Cord Blood Cells for Brain Injury in Term Newborns https://ClinicalTrials.gov/show/NCT01649648 Completed National University Hospital, Singapore 2013-11-30
NCT01546636 The Effect of Ventilation on Cerebral Oxygenation in the Sitting Position https://ClinicalTrials.gov/show/NCT01546636 Completed NorthShore University HealthSystem 2013-07-31
NCT01471015 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy https://ClinicalTrials.gov/show/NCT01471015 Completed University of Utah 2014-01-31
NCT01443962 The Effect of Positive End Expiratory Pressure (PEEP) During Laparoscopic Cholecystectomy https://ClinicalTrials.gov/show/NCT01443962 Completed Gachon University Gil Medical Center 2012-03-31
NCT01436812 Effect of Positive End Expiratory Pressure (PEEP) on Cerebral Oxymetry During Laparoscopy https://ClinicalTrials.gov/show/NCT01436812 Completed Gachon University Gil Medical Center 2012-09-30
NCT01436799 Desflurane Versus Propofol in the Sitting Position https://ClinicalTrials.gov/show/NCT01436799 Completed Gachon University Gil Medical Center 2011-08-31
NCT04325230 Prognostic Value of Arterial Spin Labeling Brain Perfusion MRI in Term Neonates With Hypoxic-ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT04325230 Recruiting University Hospital, Bordeaux 2022-07-15
NCT04261335 The Clinical Trial of CL2020 Cells for Neonatal Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT04261335 Recruiting Nagoya University 2021-12-31
NCT04188132 EEG Based BCI for Upper Limb Rehabilitation in Stroke https://ClinicalTrials.gov/show/NCT04188132 Recruiting University of Houston 2020-01-31
NCT04167527 Endovascular Therapy for Low NIHSS Ischemic Strokes https://ClinicalTrials.gov/show/NCT04167527 Recruiting Emory University 2021-01-31
NCT04063215 A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT04063215 Recruiting Hope Biosciences 2021-08-29
NCT04047563 Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke https://ClinicalTrials.gov/show/NCT04047563 Recruiting Pharmazz, Inc. 2020-06-30
NCT03938311 Time Window for Early Mobilization After Acute Ischemic Stroke https://ClinicalTrials.gov/show/NCT03938311 Recruiting China Stroke Databank Center 2022-02-28
NCT03913221 Caffeine for Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT03913221 Recruiting University of North Carolina, Chapel Hill 2020-08-31
NCT03837717 The Impact of Holding on Stress and Bonding in Mother-Infant Pairs During Therapeutic Hypothermia https://ClinicalTrials.gov/show/NCT03837717 Recruiting Maine Medical Center 2020-10-31
NCT03806816 Use of Melatonin for Neuroprotection in Asphyxiated Newborns https://ClinicalTrials.gov/show/NCT03806816 Recruiting University Hospital of Ferrara 2021-12-31
NCT03745092 The Efficacy of Normobaric Oxygen on Chronic Cerebral Ischemia https://ClinicalTrials.gov/show/NCT03745092 Completed Capital Medical University 2019-12-31
NCT03712085 Using fMRI and sEMG to Evaluate the Effects and Mechanism on Abdominal Acupuncture Combined With Upper Limb Rehabilitation Training on Brain Plasticity of Hemiplegic Patients With Stroke https://ClinicalTrials.gov/show/NCT03712085 Recruiting Guangzhou University of Traditional Chinese Medicine 2021-01-31
NCT03706768 Degradation of the Glycocalyx in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage https://ClinicalTrials.gov/show/NCT03706768 Recruiting University of Virginia 2020-05-01
NCT03635450 Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE https://ClinicalTrials.gov/show/NCT03635450 Active, not recruiting Duke University 2019-07-28
NCT03448159 Fluoxetine Opens Window to Improve Motor Recovery After Stroke https://ClinicalTrials.gov/show/NCT03448159 Recruiting University Health Network, Toronto 2020-09-30
NCT01241019 Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia https://ClinicalTrials.gov/show/NCT01241019 Completed Azienda Ospedaliero, Universitaria Meyer 2013-12-31
NCT01206283 A Study Comparing Modified Lund Concept and Cerebral Perfusion Pressure-targeted Therapy in Secondary Brain Ischaemia. https://ClinicalTrials.gov/show/NCT01206283 Completed University of Sarajevo 2008-06-30
NCT01059461 Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT01059461 Completed Ain Shams University 2013-09-30
NCT01019733 Intrathecal Stem Cells in Brain Injury https://ClinicalTrials.gov/show/NCT01019733 Completed Hospital Universitario Dr. Jose E. Gonzalez 2010-04-30
NCT00987922 Mild Hypothermia in Acute Ischemic Stroke https://ClinicalTrials.gov/show/NCT00987922 Completed University of Helsinki 2011-09-30
NCT00945789 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) https://ClinicalTrials.gov/show/NCT00945789 Completed Tanta University 2008-12-31
NCT00934700 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia https://ClinicalTrials.gov/show/NCT00934700 Completed Imperial College London 2014-09-30
NCT00890409 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT00890409 Completed Fudan University 2004-06-30
NCT00879892 Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest Patients https://ClinicalTrials.gov/show/NCT00879892 Completed Turku University Hospital 2014-09-30
NCT00871715 Arm Rehabilitation Study After Stroke https://ClinicalTrials.gov/show/NCT00871715 Completed University of Southern California 2014-02-28
NCT00829361 Stroke Telemedicine for Arizona Rural Residents Trial https://ClinicalTrials.gov/show/NCT00829361 Completed Mayo Clinic 2011-10-31
NCT00822302 Trial to Evaluate the Ability of a Single Infusion of High-Density Lipoprotein (HDL) to Modulate Markers of Cerebral Ischaemia https://ClinicalTrials.gov/show/NCT00822302 Completed St George’s, University of London 2008-12-31
NCT00808704 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy https://ClinicalTrials.gov/show/NCT00808704 Completed Zhengzhou University 2008-07-31
NCT04046484 PMZ-1620 (Sovateltide) in Acute Ischemic Stroke Patients https://ClinicalTrials.gov/show/NCT04046484 Completed Pharmazz, Inc. 2019-04-12
NCT02894866 Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT02894866 Recruiting Nanfang Hospital of Southern Medical University 2020-09-30
NCT00737334 EEG, Cerebral Oximetry, and Arterial to Jugular Venous Lactate to Assess Cerebral Ischemia During Carotid Endarterectomy https://ClinicalTrials.gov/show/NCT00737334 Completed University of Manitoba 2009-10-31
NCT00719407 Neonatal Erythropoietin in Asphyxiated Term Newborns https://ClinicalTrials.gov/show/NCT00719407 Completed University of California, San Francisco 2011-09-30
NCT00624871 Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT00624871 Completed Al-Azhar University 2006-04-30
NCT00620711 Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT00620711 Completed Vanderbilt University Medical Center 2013-07-31
NCT00614744 Late Hypothermia for Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT00614744 Completed NICHD Neonatal Research Network 2016-06-30
NCT00598819 A Prospective Study of a New Device for Monitoring Cerebral Oxygenation on Healthy Volunteers https://ClinicalTrials.gov/show/NCT00598819 Completed University of California, Irvine 2009-05-31
NCT00593242 Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT00593242 Completed Duke University 2017-01-31
NCT00472381 Efficacy and Safety of Continuous Intravenous Versus Usual Subcutaneous Insulin in Acute Ischemic Stroke https://ClinicalTrials.gov/show/NCT00472381 Completed Assistance Publique - Hôpitaux de Paris 2012-06-30
NCT00383305 CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT00383305 Completed Olympic Medical NA
NCT00343174 Intravenous Ancrod for the Treatment of Acute Ischemic Stroke Within 6 Hours After Onset of Symptoms https://ClinicalTrials.gov/show/NCT00343174 Completed Heidelberg University NA
NCT00318071 Multi MERCI (Mechanical Embolus Removal in Cerebral Ischemia [MERCIâ„¢]) https://ClinicalTrials.gov/show/NCT00318071 Completed Stryker Neurovascular 2006-12-31
NCT00190047 Effects Of DP-b99 On Neurological Function In Subjects With Acute Ischemic Hemispheric Stroke https://ClinicalTrials.gov/show/NCT00190047 Completed D-Pharm Ltd. NA
NCT00161070 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial https://ClinicalTrials.gov/show/NCT00161070 Completed UMC Utrecht NA
NCT00147316 Japan Alteplase Clinical Trial (J-ACT): Efficacy and Safety Study of Tissue Plasminogen Activator (Alteplase) for Ischemic Stroke https://ClinicalTrials.gov/show/NCT00147316 Completed Mitsubishi Tanabe Pharma Corporation NA
NCT00120588 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth https://ClinicalTrials.gov/show/NCT00120588 Completed University Hospital, Rouen NA
NCT00097097 Neonatal Resuscitation in Zambia https://ClinicalTrials.gov/show/NCT00097097 Completed NICHD Global Network for Women’s and Children’s Health NA
NCT00817401 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT00817401 Completed Zhengzhou University 2008-06-30
NCT00006516 Home Stimulation for Brain-Asphyxiated Infants https://ClinicalTrials.gov/show/NCT00006516 Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 2004-08-31
NCT00005772 Whole-Body Cooling for Birth Asphyxia in Term Infants https://ClinicalTrials.gov/show/NCT00005772 Completed NICHD Neonatal Research Network 2003-05-31

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03323411 End-of-life Intervention for African American Dementia Caregivers https://ClinicalTrials.gov/show/NCT03323411 Completed University of Illinois at Chicago 2016-09-10
NCT04001049 Glycemic Variability: Prognostic Impact on Acute Ischemic Stroke https://ClinicalTrials.gov/show/NCT04001049 Recruiting Instituto de Investigación Hospital Universitario La Paz 2021-06-30
NCT03314779 Combined Intracerebral and Jugular Bulb Microdialysis https://ClinicalTrials.gov/show/NCT03314779 Completed Odense University Hospital 2018-07-01
NCT03284528 Does Placenta Pathology Predict Outcome of Neonates With Hypoxic Ischemic Encephalopathy?" https://ClinicalTrials.gov/show/NCT03284528 Completed University Children’s Hospital, Zurich 2017-01-01
NCT03246243 Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk https://ClinicalTrials.gov/show/NCT03246243 Recruiting Boston Children’s Hospital 2021-12-18
NCT03179553 Heart Beat Variability in Neonatal Encephalopathy https://ClinicalTrials.gov/show/NCT03179553 Recruiting Thayyil, Sudhin 2021-07-31
NCT03129620 Pharmacokinetics of Ampicillin in Neonates With Moderate to Severe Hypoxic-Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT03129620 Completed Drexel University 2016-03-31
NCT03125759 The Association of Omentin and Ischemic Stroke https://ClinicalTrials.gov/show/NCT03125759 Recruiting Xi’an No.3 Hospital 2025-12-31
NCT03112486 Out-of-hospital Cardiac Arrest (OHCA) Biomarkers https://ClinicalTrials.gov/show/NCT03112486 Completed University of Florida 2020-01-28
NCT03032471 Swiss SOS MoCA - DCI Study https://ClinicalTrials.gov/show/NCT03032471 Recruiting Swiss SOS Study Group 2020-07-31
NCT03024021 Cerebral Oxymetry and Neurological Outcome in Therapeutic Hypothermia https://ClinicalTrials.gov/show/NCT03024021 Completed Tepecik Training and Research Hospital 2018-09-30
NCT02983786 Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor https://ClinicalTrials.gov/show/NCT02983786 Active, not recruiting University of Pennsylvania 2020-09-30
NCT02976584 Epileptic Potentials During Cardiac Surgery and Association With Postoperative Neurological Outcome https://ClinicalTrials.gov/show/NCT02976584 Completed University Hospital Inselspital, Berne 2017-11-24
NCT02948465 Impact of Neutrophil Extracellular Traps (NET) on Thrombolysis in Acute Phase of Cerebral Ischemia https://ClinicalTrials.gov/show/NCT02948465 Completed Hopital Foch 2016-12-10
NCT02800018 Correlation of Risk Factors and Severity of Hypoxic-ischaemic Encephalopathy https://ClinicalTrials.gov/show/NCT02800018 Completed University Children’s Hospital, Zurich 2017-12-31
NCT02683915 Reno-protective Effect of Brain Cooling in Newborn With Hypoxia https://ClinicalTrials.gov/show/NCT02683915 Completed Mansoura University Children Hospital 2016-09-30
NCT02676063 Long Term Prognostic of Neonatal Hypoxic Ischemic Encephalopathy With Hypothermia Treatment https://ClinicalTrials.gov/show/NCT02676063 Active, not recruiting University Hospital, Grenoble 2019-03-31
NCT02639806 General Anesthesia for Endovascular Thrombectomy; A Pilot Study. https://ClinicalTrials.gov/show/NCT02639806 Enrolling by invitation University of Saskatchewan 2020-12-31
NCT02605733 The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation https://ClinicalTrials.gov/show/NCT02605733 Active, not recruiting Sharp HealthCare 2016-12-31
NCT02545166 Validation of a Purine Biosensor in Detecting Acute Cerebral Ischaemia: Carotid Endarterectomy Model in SMARTChip https://ClinicalTrials.gov/show/NCT02545166 Recruiting University Hospitals Coventry and Warwickshire NHS Trust 2019-12-31
NCT02455830 Cytokines Associated With Cord Blood Cell Therapy for Neonatal Encephalopathy https://ClinicalTrials.gov/show/NCT02455830 Active, not recruiting Neonatal Encephalopathy Consortium, Japan 2020-03-31
NCT02389647 Identification of Novel Molecular Markers for Cerebral Ischemia From Patients With Minor and Devastating Ischemic Injury https://ClinicalTrials.gov/show/NCT02389647 Completed St. Joseph’s Hospital and Medical Center, Phoenix 2019-10-24
NCT02351518 Cerebral Autoregulation and Vasospasm in Patients With TBI https://ClinicalTrials.gov/show/NCT02351518 Completed University of Maryland, Baltimore 2017-06-30
NCT02349672 Clinical Utility of Serum Biomarkers for the Management of Neonatal Hypoxic Ischemic Encephalopathy (Control Levels) https://ClinicalTrials.gov/show/NCT02349672 Completed University of Florida 2017-06-30
NCT02310191 Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting https://ClinicalTrials.gov/show/NCT02310191 Completed University Hospital Ostrava 2014-11-30
NCT02264808 Developmental Outcomes https://ClinicalTrials.gov/show/NCT02264808 Completed University of Florida 2018-12-03
NCT02260271 Florida Neonatal Neurologic Network https://ClinicalTrials.gov/show/NCT02260271 Enrolling by invitation University of Florida 2021-01-31
NCT02198183 Total Shoulder Arthroplasty Near-infrared Spectroscopy https://ClinicalTrials.gov/show/NCT02198183 Completed Hospital for Special Surgery, New York 2015-05-31
NCT02147275 Monitoring Hypertensive Patients’s Cerebral Oxygen Saturation https://ClinicalTrials.gov/show/NCT02147275 Completed Huazhong University of Science and Technology 2014-11-30
NCT02051894 NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT02051894 Completed Brighton and Sussex University Hospitals NHS Trust 2016-09-30
NCT02019147 BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy. https://ClinicalTrials.gov/show/NCT02019147 Completed University College Cork 2017-08-31
NCT01955642 Evaluation of the Biological Response to Clopidogrel in Patients With Ischemic Stroke https://ClinicalTrials.gov/show/NCT01955642 Completed Centre Hospitalier Universitaire de Saint Etienne 2015-12-31
NCT01897883 Dyslipidemia Management in Chinese Post Stroke Patients https://ClinicalTrials.gov/show/NCT01897883 Completed AstraZeneca 2014-08-31
NCT01747863 Prospective Research in Infants With Mild Encephalopathy https://ClinicalTrials.gov/show/NCT01747863 Completed McGill University Health Centre/Research Institute of the McGill University Health Centre 2015-12-31
NCT01713491 Pre-stroke Cognitive Status and Thrombolytic Therapy https://ClinicalTrials.gov/show/NCT01713491 Completed University Hospital, Lille 2014-12-31
NCT01582737 Xarelto [SPAF] Post-marketing Surveillance in Japan https://ClinicalTrials.gov/show/NCT01582737 Completed Bayer 2019-03-31
NCT01560520 Physical Activity Immediately After Acute Cerebral Ischemia https://ClinicalTrials.gov/show/NCT01560520 Completed Hillerod Hospital, Denmark 2012-09-30
NCT01481207 Magnetic Resonance Imaging and Spectroscopy Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT01481207 Completed University Children’s Hospital, Zurich 2019-07-09
NCT01378000 Study on Continuous Intravenous of Unfractionated Heparin (UFH) to Treat Progressive Cerebral Infarction https://ClinicalTrials.gov/show/NCT01378000 Completed Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine 2010-08-31
NCT04445649 Prognostic Factors to Regain Consciousness https://ClinicalTrials.gov/show/NCT04445649 Recruiting BDH-Klinik Hessisch Oldendorf 2023-06-15
NCT04198792 Predictors for Survival and Good Neurological Outcome in E-CPR and Non CPR Treated Patients https://ClinicalTrials.gov/show/NCT04198792 Recruiting Sahlgrenska University Hospital, Sweden 2030-01-01
NCT03962127 MIDNOR-STROKE- a Long Term Follow-up Study of Patients With First Ever Ischemic Stroke in Central Norway https://ClinicalTrials.gov/show/NCT03962127 Active, not recruiting Norwegian University of Science and Technology 2026-08-31
NCT03941015 Tissue Oxygenation During Treatment of Infant Congenital Heart Defects https://ClinicalTrials.gov/show/NCT03941015 Recruiting Beijing Anzhen Hospital 2020-07-31
NCT03835039 The Ability of NIRS to Predict Brain Injury in Hypoxic Ischemic Encephalopathy https://ClinicalTrials.gov/show/NCT03835039 Recruiting Albany Medical College 2024-12-31
NCT03640494 Bedside Optical Retinal Assessment of Hypoxic Ischemic Encephalopathy in Infants https://ClinicalTrials.gov/show/NCT03640494 Recruiting Duke University 2020-08-31
NCT03607565 A New Parameter Derived From DSA to Evaluate Anterior Cerebral Perfusion https://ClinicalTrials.gov/show/NCT03607565 Recruiting Xi’an No.3 Hospital 2023-07-15
NCT03592563 CUHK Brain Health Longitudinal Study https://ClinicalTrials.gov/show/NCT03592563 Recruiting Chinese University of Hong Kong 2038-12-31
NCT03577093 Molecular Mechanisms of microRNA-494 Involving in Cerebral Ischemia https://ClinicalTrials.gov/show/NCT03577093 Recruiting Capital Medical University 2021-12-31
NCT03555643 Evaluation of the HARM for the Detection of a Cerebral Ischemia in TIA/TNA Patients https://ClinicalTrials.gov/show/NCT03555643 Recruiting Universitätsmedizin Mannheim 2020-06-30
NCT03543371 Neuropsychological Outcome After Cardiac Arrest https://ClinicalTrials.gov/show/NCT03543371 Recruiting Region Skane 2021-07-31
NCT01187420 Bilateral Bispectral Index (BIS) Study https://ClinicalTrials.gov/show/NCT01187420 Completed Icahn School of Medicine at Mount Sinai 2010-10-31
NCT01092637 The TOBY Children Study https://ClinicalTrials.gov/show/NCT01092637 Completed Imperial College London 2013-08-31
NCT04370028 Study on Efficacy and Safety of Divaza in Patients With Chronic Cerebral Ischemia and Cognitive Disorders https://ClinicalTrials.gov/show/NCT04370028 Completed Materia Medica Holding 2017-01-31
NCT01614080 Outcome of Patients Treated by iv Rt-PA for Cerebral Ischaemia According to the Ratio Sc-tPA/Tc-tPA https://ClinicalTrials.gov/show/NCT01614080 Completed University Hospital, Lille 2014-11-30
NCT01483495 Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study https://ClinicalTrials.gov/show/NCT01483495 Completed University of California, Irvine 2011-12-31
NCT03744481 Becoming Children With Perinatal Anoxo-Ischemic Encephalopathy Without Indication of Therapeutic Hypothermia https://ClinicalTrials.gov/show/NCT03744481 Completed Hospices Civils de Lyon 2019-08-02
NCT03485781 Propofol-induced EEG Changes in Hypoxic Brain Injury https://ClinicalTrials.gov/show/NCT03485781 Completed University of Oulu 2019-07-10
NCT00590980 Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) https://ClinicalTrials.gov/show/NCT00590980 Completed University of Illinois at Chicago 2014-07-31
NCT00490295 Biomarkers for Detection of Brain Ischemia https://ClinicalTrials.gov/show/NCT00490295 Completed Emory University 2010-01-31
NCT00375908 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury https://ClinicalTrials.gov/show/NCT00375908 Completed Johns Hopkins University 2008-12-31
NCT00207961 The Threshold Value of Regional Cerebral Oxygenation in Detecting Cerebral Ischemia https://ClinicalTrials.gov/show/NCT00207961 Completed China Medical University Hospital NA
NCT00015717 Magnetic Resonance Imaging to Investigate Silent Strokes During Neck and Skull Angioplasty https://ClinicalTrials.gov/show/NCT00015717 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT04337697 Neonatal Seizure Registry - Developmental Functional EValuation https://ClinicalTrials.gov/show/NCT04337697 Recruiting University of California, San Francisco 2024-02-29
NCT03318432 Stroke Recovery Initiative - Registry for Stroke Research Studies https://ClinicalTrials.gov/show/NCT03318432 Recruiting University of California, San Francisco 2022-10-27
NCT03281590 Stroke and Cerebrovascular Diseases Registry https://ClinicalTrials.gov/show/NCT03281590 Recruiting University of New Mexico 2021-12-31
NCT03161275 Measurement of the Cerebral Saturation for Assessment of Safety of Epidural Anaesthesia During Abdominal Surgery https://ClinicalTrials.gov/show/NCT03161275 Completed Jagiellonian University 2013-03-31
NCT02900521 Population-based Brest Stroke Registry https://ClinicalTrials.gov/show/NCT02900521 Recruiting University Hospital, Brest 2016-08-31
NCT02507856 Prospective Record Of the Use of Dabigatran in Patients With Acute Stroke or TIA https://ClinicalTrials.gov/show/NCT02507856 Recruiting University Hospital, Essen 2021-06-30
NCT02320539 MicroRNA Diagnostics in Subarachnoid Hemorrhage 2 https://ClinicalTrials.gov/show/NCT02320539 Completed Rigshospitalet, Denmark 2015-05-31
NCT02231060 Study for the Improvement of Long-Term Outcome Prediction in Patients in Coma After Cardiac Arrest https://ClinicalTrials.gov/show/NCT02231060 Completed Ludwig-Maximilians - University of Munich 2018-12-06
NCT03985176 Delayed Cerebral Ischaemia and Coagulation Alterations After Aneurysmal Subarachnoid Haemorrhage https://ClinicalTrials.gov/show/NCT03985176 Recruiting Tampere University Hospital 2021-08-31
NCT03214705 Role of CT Perfusion in Predicting Poor Outcome After Subarachnoid Hemorrhage https://ClinicalTrials.gov/show/NCT03214705 Completed Assiut University 2018-02-01